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Treating brain disease with Gamma Knife Perfexion
Imagine undergoing brain surgery as an outpatient with reduced pain, a brief recovery period and no incision. Hoag Gamma Knife Center is the only facility in Orange County providing this effective treatment option for patients with brain disease.
And Hoag Neurosciences Center is the now the first center in Southern California to employ the revolutionary Leksell Gamma Knife® Perfexion™—the newest, most efficient and precise radiosurgical device available. With an expanded treatment area and enhanced accuracy, this Gamma Knife technology benefits significantly more patients who can now be treated with Gamma Knife radiosurgery instead of a more invasive procedure.
Gamma Knife is the gold standard in minimally invasive neurosurgery
Backed by over two decades of clinical application in the U.S. with unsurpassed outcomes, Gamma Knife is recognized as the gold standard in minimally invasive neurosurgery. Hoag Hospital’s new Gamma Knife Perfexion takes the gold standard platinum.
The Gamma Knife administers a single dose of radiation to stop and/or reduce the growth of abnormal tissue by destroying the DNA mapping of the cells, which renders them unable to divide. 192 precise gamma ray beams are focused on the abnormal tissue area with the area of intersection conforming to the size and shape of the tumor.
“With Gamma Knife Perfexion, we’re able to prevent injury to surrounding healthy tissue while delivering a powerful dose to the targeted tumor,” explains accomplished Gamma Knife surgeon, Chris Duma, MD, medical director of Hoag’s Brain Tumor Program. “We utilize the Gamma Knife most frequently in treating brain metastases, where we’ll often incorporate it in conjunction with surgery, radiation therapy or chemotherapy. And, for high-risk patients that may not be able to tolerate an open-skull surgery, Gamma Knife offers an effective treatment alternative.”
The team of specialists at Hoag Gamma Knife Center, a program of Hoag Neurosciences Center, treats more than 200 patients annually, adding months and even years to the lives of those treated with this state-of-the-art technology. And with Hoag’s upgraded Gamma Knife system, Hoag specialists are now able to offer this minimally invasive approach to even more patients—treating areas of the brain, skull base and cervical spine that could not previously be reached without surgical incision.
With Gamma Knife Perfexion Hoag specialists can now treat tumors that were unreachable using previous technology
Perfexion’s anatomical reach has been expanded to treat the brain, skull base and cervical spine, which allows Hoag specialists to address difficult to reach tumors that were not previously treatable when compared to earlier generations of Gamma Knife and current competing technologies. Additionally, while other radiosurgical tools require more than one session to treat multiple brain lesions, Gamma Knife Perfexion can safely and effectively irradiate multiple lesions in a single treatment session.
“The enhanced design of Gamma Knife Perfexion provides us with almost unlimited ability for sculpting the treatment plan with incomparable accuracy,” confirms Dr. Duma. “This more precise system can now be used to treat patients whose tumors are very near vital parts of the body, such as the optic nerve.”
Radiosurgery with the new Gamma Knife Perfexion remains an outpatient procedure, free of the risks of invasive brain surgery. Following Gamma Knife treatment, patients can immediately return to preoperative lifestyle without any need for intensive care or extended hospitalization.
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Southern California’s First Gamma Knife Perfexion Provides Most Advanced Noninvasive Treatment System for Brain Disease at Hoag Hospital More...


Medical Director Chris Duma, MD discusses new Gamma Knife Perfexion at Hoag Hospital, click to watch video

Gamma Knife Perfexion, click to watch animation
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